Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations

TG Martin, LA Leinwand - Journal of Experimental Biology, 2024 - journals.biologists.com
Some vertebrates evolved to have a remarkable capacity for anatomical and physiological
plasticity in response to environmental challenges. One example of such plasticity can be …

The elusive hypertrophy of the python heart

B Jensen, T Wang - Physiology, 2024 - journals.physiology.org
The Burmese python, one of the world's largest snakes, has reached celebrity status for its
dramatic physiological responses associated with digestion of enormous meals. The meals …

Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons

C Crocini, KC Woulfe, CD Ozeroff, S Perni… - Proceedings of the …, 2024 - pnas.org
Constricting pythons, known for their ability to consume infrequent, massive meals, exhibit
rapid and reversible cardiac hypertrophy following feeding. Our primary goal was to …

Single-cell resolution of intestinal regeneration in pythons without crypts illuminates conserved vertebrate regenerative mechanisms

AK Westfall, SS Gopalan, JC Kay, TS Tippetts… - Proceedings of the …, 2024 - pnas.org
Canonical models of intestinal regeneration emphasize the critical role of the crypt stem cell
niche to generate enterocytes that migrate to villus ends. Burmese pythons possess extreme …

Utility of the burmese Python as a model for studying plasticity of extreme physiological systems

Y Tan, TG Martin, BC Harrison, LA Leinwand - Journal of muscle research …, 2023 - Springer
Non-traditional animal models present an opportunity to discover novel biology that has
evolved to allow such animals to survive in extreme environments. One striking example is …

A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1

TG Martin, DR Hunt, SJ Langer, Y Tan, CC Ebmeier… - …, 2024 - pmc.ncbi.nlm.nih.gov
The heart is a highly plastic organ that responds to diverse stimuli to modify form and
function. The molecular mechanisms of adaptive physiological cardiac hypertrophy are well …

Diagnostic Clinical Pathology of Boas and Pythons

AN Schnelle - Veterinary Clinics: Exotic Animal Practice, 2022 - vetexotic.theclinics.com
Much is unknown about many aspects of diagnostic clinical pathology for reptiles,
particularly snakes. Although we focus on boas and pythons, references assessing other …

Stress Response Pathways and the Origins of Novelty: How Snakes Regenerate Organs and Regulate Venom

AK Westfall - 2023 - search.proquest.com
Snakes have captured evolutionary biologists' attention for decades as extreme examples of
adaptive evolution models for studying how novel and extreme traits evolve in nature, but …

Dynamic Physiological Remodeling in Post-Prandial Burmese Pythons

Y Tan - 2023 - search.proquest.com
Non-traditional animal models present an opportunity to discover novel biology that has
evolved to allow such animals to survive in extreme environments and to potentially extend …