Mechanisms of deubiquitinase specificity and regulation
Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …
as it regulates a plethora of cellular processes in distinct manners. Simple …
Deubiquitylases from genes to organism
Ubiquitylation is a major posttranslational modification that controls most complex aspects of
cell physiology. It is reversed through the action of a large family of deubiquitylating …
cell physiology. It is reversed through the action of a large family of deubiquitylating …
Clinical features, neurogenetics and neuropathology of the polyglutamine spinocerebellar ataxias type 1, 2, 3, 6 and 7
The spinocerebellar ataxias type 1 (SCA1), 2 (SCA2), 3 (SCA3), 6 (SCA6) and 7 (SCA7) are
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs) …
genetically defined autosomal dominantly inherited progressive cerebellar ataxias (ADCAs) …
[HTML][HTML] Pathogenesis of SCA3 and implications for other polyglutamine diseases
Tandem repeat diseases include the neurodegenerative disorders known as polyglutamine
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …
(polyQ) diseases, caused by CAG repeat expansions in the coding regions of the respective …
The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation
Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …
processes in eukaryotes through highly specific modification of numerous cellular proteins …
Toward understanding Machado–Joseph disease
M do Carmo Costa, HL Paulson - Progress in neurobiology, 2012 - Elsevier
Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3 (SCA3), is
the most common inherited spinocerebellar ataxia and one of many polyglutamine …
the most common inherited spinocerebellar ataxia and one of many polyglutamine …
Post-translational modifications of deubiquitinating enzymes: expanding the ubiquitin code
Y Wang, F Wang - Frontiers in pharmacology, 2021 - frontiersin.org
Post-translational modifications such as ubiquitination play important regulatory roles in
several biological processes in eukaryotes. This process could be reversed by …
several biological processes in eukaryotes. This process could be reversed by …
Post-translational modifications: regulators of neurodegenerative proteinopathies
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …
Machado–Joseph disease/spinocerebellar ataxia type 3: lessons from disease pathogenesis and clues into therapy
Abstract Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3
(SCA 3), is an incurable disorder, widely regarded as the most common form of …
(SCA 3), is an incurable disorder, widely regarded as the most common form of …
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP
The mechanisms by which ubiquitin ligases are regulated remain poorly understood. Here
we describe a series of molecular events that coordinately regulate CHIP, a neuroprotective …
we describe a series of molecular events that coordinately regulate CHIP, a neuroprotective …