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The lung microbiome: progress and promise
The healthy lung was long thought of as sterile, but recent advances using molecular
sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely …
sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely …
Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …
Inflammatory endotype–associated airway microbiome in chronic obstructive pulmonary disease clinical stability and exacerbations: a multicohort longitudinal …
Z Wang, N Locantore, K Haldar… - American journal of …, 2021 - atsjournals.org
Rationale: Understanding the role of the airway microbiome in chronic obstructive
pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome …
pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome …
The lung microbiome: a new frontier for lung and brain disease
J Chen, T Li, C Ye, J Zhong, JD Huang, Y Ke… - International Journal of …, 2023 - mdpi.com
Due to the limitations of culture techniques, the lung in a healthy state is traditionally
considered to be a sterile organ. With the development of non-culture-dependent …
considered to be a sterile organ. With the development of non-culture-dependent …
Molecular accounting and profiling of human respiratory microbial communities: toward precision medicine by targeting the respiratory microbiome for disease …
The wide diversity of microbiota at the genera and species levels across sites and
individuals is related to various causes and the observed differences between individuals …
individuals is related to various causes and the observed differences between individuals …
Nasal bacterial microbiome differs between healthy controls and those with asthma and allergic rhinitis
M Chen, S He, P Miles, C Li, Y Ge, X Yu… - Frontiers in cellular …, 2022 - frontiersin.org
Perturbation of the microbiome has numerous associations with the phenotypes and
progression in chronic airways disease. However, the differences in the nasal microbiome in …
progression in chronic airways disease. However, the differences in the nasal microbiome in …
Role of the microbiome in oral cancer occurrence, progression and therapy
Z Li, Y Liu, L Zhang - Microbial Pathogenesis, 2022 - Elsevier
The oral cavity, like other digestive or mucosal sites, contains a site-specific microbiome that
plays a significant role in maintaining health and homeostasis. Strictly speaking, the …
plays a significant role in maintaining health and homeostasis. Strictly speaking, the …
The role of the respiratory microbiome in asthma
CD Campbell, M Gleeson, I Sulaiman - Frontiers in Allergy, 2023 - frontiersin.org
Asthma is a common airways disease and the human microbiome plays an increasingly
recognised role in asthma pathogenesis. Furthermore, the respiratory microbiome varies …
recognised role in asthma pathogenesis. Furthermore, the respiratory microbiome varies …
Loss of airway phylogenetic diversity is associated with clinical and pathobiological markers of disease development in chronic obstructive pulmonary disease
Rationale: The airway microbiome has the potential to shape chronic obstructive pulmonary
disease (COPD) pathogenesis, but its relationship to outcomes in milder disease is …
disease (COPD) pathogenesis, but its relationship to outcomes in milder disease is …
Immunomodulatory role of oral microbiota in inflammatory diseases and allergic conditions
In recent years, the interplay between oral microbiota and systemic disease has gained
attention as poor oral health is associated with several pathologies. The oral microbiota …
attention as poor oral health is associated with several pathologies. The oral microbiota …