The lung microbiome: progress and promise

SA Whiteside, JE McGinniss, RG Collman - The Journal of Clinical …, 2021 - jci.org
The healthy lung was long thought of as sterile, but recent advances using molecular
sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely …

Eosinophil knockout humans: uncovering the role of eosinophils through eosinophil-directed biological therapies

EA Jacobsen, DJ Jackson, E Heffler… - Annual review of …, 2021 - annualreviews.org
The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

Inflammatory endotype–associated airway microbiome in chronic obstructive pulmonary disease clinical stability and exacerbations: a multicohort longitudinal …

Z Wang, N Locantore, K Haldar… - American journal of …, 2021 - atsjournals.org
Rationale: Understanding the role of the airway microbiome in chronic obstructive
pulmonary disease (COPD) inflammatory endotypes may help to develop microbiome …

The lung microbiome: a new frontier for lung and brain disease

J Chen, T Li, C Ye, J Zhong, JD Huang, Y Ke… - International Journal of …, 2023 - mdpi.com
Due to the limitations of culture techniques, the lung in a healthy state is traditionally
considered to be a sterile organ. With the development of non-culture-dependent …

Molecular accounting and profiling of human respiratory microbial communities: toward precision medicine by targeting the respiratory microbiome for disease …

AR Alsayed, A Abed, HA Khader… - International Journal of …, 2023 - mdpi.com
The wide diversity of microbiota at the genera and species levels across sites and
individuals is related to various causes and the observed differences between individuals …

Nasal bacterial microbiome differs between healthy controls and those with asthma and allergic rhinitis

M Chen, S He, P Miles, C Li, Y Ge, X Yu… - Frontiers in cellular …, 2022 - frontiersin.org
Perturbation of the microbiome has numerous associations with the phenotypes and
progression in chronic airways disease. However, the differences in the nasal microbiome in …

Role of the microbiome in oral cancer occurrence, progression and therapy

Z Li, Y Liu, L Zhang - Microbial Pathogenesis, 2022 - Elsevier
The oral cavity, like other digestive or mucosal sites, contains a site-specific microbiome that
plays a significant role in maintaining health and homeostasis. Strictly speaking, the …

The role of the respiratory microbiome in asthma

CD Campbell, M Gleeson, I Sulaiman - Frontiers in Allergy, 2023 - frontiersin.org
Asthma is a common airways disease and the human microbiome plays an increasingly
recognised role in asthma pathogenesis. Furthermore, the respiratory microbiome varies …

Loss of airway phylogenetic diversity is associated with clinical and pathobiological markers of disease development in chronic obstructive pulmonary disease

K Opron, LA Begley, JR Erb-Downward… - American journal of …, 2024 - atsjournals.org
Rationale: The airway microbiome has the potential to shape chronic obstructive pulmonary
disease (COPD) pathogenesis, but its relationship to outcomes in milder disease is …

Immunomodulatory role of oral microbiota in inflammatory diseases and allergic conditions

CM Moreno, E Boeree, CMT Freitas, KS Weber - Frontiers in Allergy, 2023 - frontiersin.org
In recent years, the interplay between oral microbiota and systemic disease has gained
attention as poor oral health is associated with several pathologies. The oral microbiota …