The i-motif, a secondary structure of a four-helix formed by cytosine-rich DNA (i-DNA)
through C–C+ base pairing, is prevalent in human telomeres and promoters. This structure …

G-quadruplex and i-motif nucleic acid structures are believed to fold through kinetic
partitioning mechanisms. Such mechanisms explain the structural heterogeneity of G …

At acidic pH, cytosine-rich single-stranded DNA can be folded into a tetraplex structure
called i-motif (iM). In recent studies, the effect of monovalent cations on the stability of iM …

A new fluorescent cytosine analog “tsC” containing a trans-stilbene moiety was synthesized
and incorporated into hemiprotonated base pairs that comprise i-motif structures. Unlike …

The i-motif is a pH-responsive cytosine-rich oligonucleotide sequence that forms, under
acidic conditions, a quadruplex structure. This tunable structural switching has made the i …

In this study, we developed an isothermal fluorometric diagnostic method for DNA virus-
generating disorders such as Mpox. Our results showed that the release of a large number …

The three-dimensional structure of a biological macromolecule (BMM) determines its
biological function. Protein folding has been at the forefront of biophysical research for …

I-motifs are intercalated cytosine quadruplexes discovered in 1993, but they weren't shown
to exist in the cell nucleus until 2018. While their biological role has yet to be fully elucidated …