The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

Abstract SIRT1 (Sir2) is an NAD+-dependent deacetylase that plays critical roles in a broad
range of biological events, including metabolism, the immune response and ageing …

Research on the biology of NAD+ has been gaining momentum, providing many critical
insights into the pathogenesis of age-associated functional decline and diseases. In …

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1–
SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing …

Sirtuins such as SIRT1 are conserved protein NAD+-dependent deacylases and thus their
function is intrinsically linked to cellular metabolism. Over the past two decades …

Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular
nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in …

Brown adipose tissue (BAT) can disperse stored energy as heat. Promoting BAT-like
features in white adipose (WAT) is an attractive, if elusive, therapeutic approach to staunch …

Genetic overexpression of protein deacetylase Sir2 increases longevity in a variety of lower
organisms, and this has prompted interest in the effects of its closest mammalian …

Protein lysine acetylation is an important posttranslational modification that regulates
numerous biological processes. Targeting lysine acetylation regulatory factors, such as …