Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

The rise of regulatory RNA

KV Morris, JS Mattick - Nature Reviews Genetics, 2014 - nature.com
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Diversifying microRNA sequence and function

SL Ameres, PD Zamore - Nature reviews Molecular cell biology, 2013 - nature.com
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …

MicroRNA: biogenesis, function and role in cancer

LA MacFarlane, PR Murphy - Current genomics, 2010 - ingentaconnect.com
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the
regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Many roads to maturity: microRNA biogenesis pathways and their regulation

J Winter, S Jung, S Keller, RI Gregory… - Nature cell biology, 2009 - nature.com
MicroRNAs are important regulators of gene expression that control both physiological and
pathological processes such as development and cancer. Although their mode of action has …

A brief review on the mechanisms of miRNA regulation

Y Cai, X Yu, S Hu, J Yu - Genomics, Proteomics and …, 2009 - academic.oup.com
MicroRNAs (miRNAs) are a class of short, endogenously-initiated non-coding RNAs that
post-transcriptionally control gene expression via either translational repression or mRNA …

Evolution of microRNA diversity and regulation in animals

E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …

Functions and regulation of RNA editing by ADAR deaminases

K Nishikura - Annual review of biochemistry, 2010 - annualreviews.org
One type of RNA editing converts adenosines to inosines (A→ I editing) in double-stranded
RNA (dsRNA) substrates. A→ I RNA editing is mediated by adenosine deaminase acting on …