▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …

Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

The four mammalian neurotrophins—NGF, BDNF, NT-3 and NT-4—each bind and activate
one or more of the Trk family of receptor tyrosine kinases. Through these receptors …

Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …

Internalization and transport of a ligand-receptor complex are required to initiate cell body
responses to target-derived neurotrophin. However, it is not known whether internalized …

Target-derived neurotrophins initiate signals that begin at nerve terminals and cross long
distances to reach the cell bodies and regulate gene expression. Neurotrophin receptors …

Neurotrophins promote multiple actions on neuronal cells including cell survival and
differentiation. The best-studied neurotrophin, nerve growth factor (NGF), is a major survival …

Acentral tenet of nerve growth factor (NGF) action that is poorly understood is its ability to
mediate cytoplasmic signaling, through its receptor TrkA, that is initiated at the nerve …

To overcome the limitations of the clinical use of neurotrophins nerve growth factor (NGF)
and brain‐derived neurotrophic factor (BDNF), scientists have been trying to create their low …