The β-sheet–rich amyloid core is the defining feature of protein aggregates associated with
neurodegenerative disorders. Recent investigations have revealed that there exist multiple …

Emission fluorescence is one of the most versatile and powerful biophysical techniques
used in several scientific subjects. It is extensively applied in the studies of proteins, their …

Coarse-grained (CG) modelling with the Martini force field has come of age. By combining a
variety of bead types and sizes with a new map** approach, the newest version of the …

Liquid-liquid phase separation (LLPS) acts as an important biological phenomenon in
membraneless organelle formation. These phase-separated bodies can also act as …

Misfolding of the prion protein is linked to multiple neurodegenerative diseases. A better
understanding of the process requires the identification and structural characterization of …

The misfolding of the mammalian prion protein from its α‐helix rich cellular isoform to its β‐
sheet rich infectious isoform is associated with several neurodegenerative diseases. The …

The misfolding of the prion protein has been linked to several neurodegenerative diseases.
Despite extensive studies, the mechanism of the misfolding process remains poorly …

Transmissible Spongiform Encephalopathies are fatal neurodegenerative diseases caused
by the misfolding of the cellular prion protein (PrPC) into its pathological isoform (PrPSc) …

Paramagnetic (open-shell) systems, including transition metal ions, radical intermediates
and defect centres, are often involved in catalytic transformations. Despite the prevalence of …

Intrinsically disordered proteins (IDPs) have captured attention in the last couple of decades
due to their functional roles despite a lack of specific structure. Moreover, these proteins are …