Previously, the contribution of peripheral infection to cognitive decline was largely
overlooked however, the past 15 years have established a key role for infectious pathogens …

Senile amyloid plaques are one of the main hallmarks of Alzheimer's disease (AD). They
correspond to insoluble deposits of amyloid-ß peptides (Aß) and are responsible for the …

The interaction between the nervous and immune systems during aging is an area of avid
interest, but many aspects remain unclear. This is due, not only to the complexity of the …

In Alzheimer's disease, the contribution of inflammation is still controversially discussed. The
aim of this study was to identify a particular immune profile in the peripheral blood (PB) and …

Background The 5XFAD early onset mouse model of Alzheimer's disease (AD) is gaining
momentum. Behavioral, electrophysiological and anatomical studies have identified age …

Exposure to aluminum chloride (AlCl 3) induces progressive multiregional
neurodegeneration in animal models by promoting oxidative stress and neuroinflammation …

Recently, we have reported the presence of fungal infections in patients with Alzheimer's
disease (AD). Accordingly, fungal proteins and DNA were found in brain samples …

Background Interleukin-33 is a cytokine endowed with pro-and anti-inflammatory properties
that plays a still poorly defined role in the pathogenesis of a number of central nervous …

Alzheimer disease (AD) is the most common form of dementia in the elderly, progressively
affecting the cognitive functions with a complex diagnostic procedure that limits the time for a …

Alzheimer's disease (AD) is associated with dysregulated immune and inflammatory
responses. Emerging evidence indicates that peripheral immune activation is linked to …