Previously, the contribution of peripheral infection to cognitive decline was largely
overlooked however, the past 15 years have established a key role for infectious pathogens …

With the increase in the aging population, age‐related conditions such as dementia and
Alzheimer's disease will become ever more prevalent in society. As there is no cure for …

Senile amyloid plaques are one of the main hallmarks of Alzheimer's disease (AD). They
correspond to insoluble deposits of amyloid-ß peptides (Aß) and are responsible for the …

In Alzheimer's disease, the contribution of inflammation is still controversially discussed. The
aim of this study was to identify a particular immune profile in the peripheral blood (PB) and …

Background The 5XFAD early onset mouse model of Alzheimer's disease (AD) is gaining
momentum. Behavioral, electrophysiological and anatomical studies have identified age …

Exposure to aluminum chloride (AlCl 3) induces progressive multiregional
neurodegeneration in animal models by promoting oxidative stress and neuroinflammation …

Background Interleukin-33 is a cytokine endowed with pro-and anti-inflammatory properties
that plays a still poorly defined role in the pathogenesis of a number of central nervous …

Recently, we have reported the presence of fungal infections in patients with Alzheimer's
disease (AD). Accordingly, fungal proteins and DNA were found in brain samples …

Alzheimer's disease (AD) is associated with dysregulated immune and inflammatory
responses. Emerging evidence indicates that peripheral immune activation is linked to …

Alzheimer disease (AD) is the most common form of dementia in the elderly, progressively
affecting the cognitive functions with a complex diagnostic procedure that limits the time for a …