Comparisons of human genomes show that more base pairs are altered as a result of
structural variation—including copy number variation—than as a result of point mutations …

The transport of fluid in and around nanometer-sized objects with at least one characteristic
dimension below 100 nm enables the occurrence of phenomena that are impossible at …

DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

Nanomedicine is defined as the application of nanobiotechnology to medicine. It is a
discipline at the interface of medicine and nanobiotechnology but is not a subspecialty of …

Recent developments in micro-and nanotechnologies made possible the fabrication of
devices integrating a deterministic network of nanochannels, ie, with at least one dimension …

Recent advances in optical map** have allowed the construction of improved genome
assemblies with greater contiguity. Optical map** also enables genome comparison and …

The study of the conformation properties of macromolecules is at the heart of polymer
science. Essentially all physical properties of polymers are manifestations of the underlying …

The ability to trap an object—whether a single atom or a macroscopic entity—affects fields
as diverse as quantum optics, soft condensed-matter physics, biophysics and clinical …

Controlling the emission of bright luminescent nanoparticles by a single molecular
recognition event remains a challenge in the design of ultrasensitive probes for …

Here we explore the potential power of denaturation map** as a single-molecule
technique. By partially denaturing YOYO®-1-labeled DNA in nanofluidic channels with a …