[HTML][HTML] Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues
The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at
least in part, to a failure to recapitulate the structure, composition and functional properties of …
least in part, to a failure to recapitulate the structure, composition and functional properties of …
Modular tissue assembly strategies for biofabrication of engineered cartilage
This review describes the prospects of applying modular assembly techniques and
strategies for fabrication of advanced tissue engineered cartilage constructs. Articular …
strategies for fabrication of advanced tissue engineered cartilage constructs. Articular …
[HTML][HTML] Spatial patterning of phenotypically distinct microtissues to engineer osteochondral grafts for biological joint resurfacing
Modular biofabrication strategies using microtissues or organoids as biological building
blocks have great potential for engineering replacement tissues and organs at scale. Here …
blocks have great potential for engineering replacement tissues and organs at scale. Here …
Automated 3D bioassembly of micro-tissues for biofabrication of hybrid tissue engineered constructs
Bottom-up biofabrication approaches combining micro-tissue fabrication techniques with
extrusion-based 3D printing of thermoplastic polymer scaffolds are emerging strategies in …
extrusion-based 3D printing of thermoplastic polymer scaffolds are emerging strategies in …
Patterned, organoid-based cartilaginous implants exhibit zone specific functionality forming osteochondral-like tissues in vivo
Tissue engineered constructs have the potential to respond to the unmet medical need of
treating deep osteochondral defects. However, current tissue engineering strategies …
treating deep osteochondral defects. However, current tissue engineering strategies …
Impact of hydrogel stiffness on differentiation of human adipose-derived stem cell microspheroids
Hydrogels represent an attractive material platform for realization of three-dimensional (3D)
tissue-engineered constructs, as they have tunable mechanical properties, are compatible …
tissue-engineered constructs, as they have tunable mechanical properties, are compatible …
The Microwell-mesh: A high-throughput 3D prostate cancer spheroid and drug-testing platform
Abstract Treatment following early diagnosis of Prostate cancer (PCa) is increasingly
successful, whilst the treatment of advanced and metastatic PCa remains challenging. A …
successful, whilst the treatment of advanced and metastatic PCa remains challenging. A …
Inhibition of BMP signaling with LDN 193189 can influence bone marrow stromal cell fate but does not prevent hypertrophy during chondrogenesis
Bone morphogenetic protein (BMP) cascades are upregulated during bone marrow-derived
stromal cell (BMSC) chondrogenesis, contributing to hypertrophy and preventing effective …
stromal cell (BMSC) chondrogenesis, contributing to hypertrophy and preventing effective …
Tailored melt Electrowritten scaffolds for the generation of sheet‐like tissue constructs from multicellular spheroids
R McMaster, C Hoefner, A Hrynevich… - Advanced …, 2019 - Wiley Online Library
Melt electrowriting (MEW) is an additive manufacturing technology that is recently used to
fabricate voluminous scaffolds for biomedical applications. In this study, MEW is adapted for …
fabricate voluminous scaffolds for biomedical applications. In this study, MEW is adapted for …
[HTML][HTML] Pre-culture of human mesenchymal stromal cells in spheroids facilitates chondrogenesis at a low total cell count upon embedding in biomaterials to generate …
Material-assisted cartilage tissue engineering has limited application in cartilage treatment
due to hypertrophic tissue formation and high cell counts required. This study aimed at …
due to hypertrophic tissue formation and high cell counts required. This study aimed at …