The multifaceted nature of antimicrobial peptides: Current synthetic chemistry approaches and future directions

BH Gan, J Gaynord, SM Rowe, T Deingruber… - Chemical Society …, 2021 - pubs.rsc.org
Bacterial infections caused by 'superbugs' are increasing globally, and conventional
antibiotics are becoming less effective against these bacteria, such that we risk entering a …

Antimicrobial peptides: an update on classifications and databases

A Bin Hafeez, X Jiang, PJ Bergen, Y Zhu - International journal of …, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are distributed across all kingdoms of life and are an
indispensable component of host defenses. They consist of predominantly short cationic …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Advances of antimicrobial peptide‐based biomaterials for the treatment of bacterial infections

G Li, Z Lai, A Shan - Advanced Science, 2023 - Wiley Online Library
Owing to the increase in multidrug‐resistant bacterial isolates in hospitals globally and the
lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have …

Insect antimicrobial peptides: potential weapons to counteract the antibiotic resistance

MD Manniello, A Moretta, R Salvia, C Scieuzo… - Cellular and Molecular …, 2021 - Springer
Misuse and overuse of antibiotics have contributed in the last decades to a phenomenon
known as antibiotic resistance which is currently considered one of the principal threats to …

Strategies employed in the design of antimicrobial peptides with enhanced proteolytic stability

Z Lai, X Yuan, H Chen, Y Zhu, N Dong, A Shan - Biotechnology Advances, 2022 - Elsevier
Due to the alarming develo** rate of multidrug-resistant bacterial pathogens, the
development and modification of antimicrobial peptides (AMPs) are unprecedentedly active …

Antimicrobial peptides: a new frontier in antifungal therapy

G Buda De Cesare, SA Cristy, DA Garsin, MC Lorenz - MBio, 2020 - Am Soc Microbiol
Invasive fungal infections in humans are generally associated with high mortality, making
the choice of antifungal drug crucial for the outcome of the patient. The limited spectrum of …

The plant peptidome: an expanding repertoire of structural features and biological functions

P Tavormina, B De Coninck, N Nikonorova… - The Plant …, 2015 - academic.oup.com
Peptides fulfill a plethora of functions in plant growth, development, and stress responses.
They act as key components of cell-to-cell communication, interfere with signaling and …

Embracing the era of antimicrobial peptides with marine organisms

P Chen, T Ye, C Li, P Praveen, Z Hu, W Li… - Natural Product …, 2024 - pubs.rsc.org
Covering: 2018 to Jun of 2023 The efficiency of traditional antibiotics has been undermined
by the proliferation of antibiotic-resistant pathogenic microorganisms, necessitating the …

In pursuit of next-generation therapeutics: Antimicrobial peptides against superbugs, their sources, mechanism of action, nanotechnology-based delivery, and clinical …

A Thakur, A Sharma, HK Alajangi, PK Jaiswal… - International Journal of …, 2022 - Elsevier
Antimicrobial peptides (AMPs) attracted attention as potential source of novel antimicrobials.
Multi-drug resistant (MDR) infections have emerged as a global threat to public health in …