Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

A major focus in the study of metabolism and disposition of trichloroethylene (TCE) is to
identify metabolites that can be used reliably to assess flux through the various pathways of …

Cisplatin is one of the most widely used chemotherapeutic agents for the treatment of
several human malignancies. The efficacy of cisplatin is dose dependent, but the significant …

Technologies currently employed to find and identify drug metabolites in complex biological
matrices generally yield results that offer a comprehensive picture of the drug metabolite …

The glutathione S-transferases (GST)(EC 2.5. 1.18) are a family of multifunctional proteins
that function both as important enzymes of detoxification and intracellular binding proteins …

Glutathione (γ-glutamyl-l-cysteinylglycine; GSH) is present in high concentrations in most
living cells and participates in a variety of vital cellular reactions. In particular, GSH protects …

Living organisms are continuously exposed to xenobiotics. The major phase of enzymatic
detoxification in many species is the conjugation of activated xenobiotics to reduced …

The chlorinated solvent trichloroethylene (TCE) is a ubiquitous environmental pollutant. The
carcinogenic hazard of TCE was the subject of a 2012 evaluation by a Working Group of the …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by large fluid-filled
cysts and progressive deterioration of renal function necessitating renal replacement …

Many potentially toxic electrophilic xenobiotics and some endogenous compounds are
detoxified by conversion to the corresponding glutathione S-conjugate, which is metabolized …