Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease | New England Journal of
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Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity
and mortality worldwide. COPD exacerbations are associated with a worsening of lung …

Background Most guidelines recommend either a long-acting beta-agonist (LABA) plus an
inhaled glucocorticoid or a long-acting muscarinic antagonist (LAMA) as the first-choice …

The efficacy, safety and positioning of inhaled corticosteroids (ICS) in the treatment of
patients with chronic obstructive pulmonary disease (COPD) is much debated, since it can …

Severe exacerbations of COPD, ie, those leading to hospitalization, have profound clinical
implications for patients and significant economic consequences for society. The prevalence …

Chronic obstructive pulmonary disease patient care must include confirming a diagnosis
with postbronchodilator spirometry. Because of the clinical heterogeneity and the reality that …

Background Roflumilast reduces exacerbations in patients with severe chronic obstructive
pulmonary disease. Its effect in patients using fixed combinations of inhaled corticosteroids …

Rationale: Acute exacerbations of chronic obstructive pulmonary disease (AECOPDs) are
important adverse events in the natural history of chronic obstructive pulmonary disease …

Purpose Chronic obstructive pulmonary disease (COPD) is a significant cause of morbidity
and mortality in the United States. Exacerbations—acute worsening of COPD symptoms …

Background Conventional measures to evaluate COPD may fail to capture systemic
problems, particularly musculoskeletal weakness and cardiovascular disease. Identifying …