Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Prion diseases are transmissible, invariably fatal, neurodegenerative diseases which
include Creutzfeldt–Jakob disease (CJD) in humans and bovine spongiform …

Prion diseases are fatal neurodegenerative and infectious disorders for which no
therapeutic or prophylactic regimens exist. In search of cellular mechanisms that play a role …

Understanding the mechanisms underlying protein misfolding and aggregation has become
a central issue in biology and medicine. Compelling evidence show that the formation of …

Prions are protein-based infectious agents that autocatalytically convert the cellular prion
protein PrP C to its pathological isoform PrP Sc. Subsequent aggregation and accumulation …

After successful launching of first and second editions of Biotechnology Fundamentals, we
thought let us find out the feedbacks from our esteemed readers, faculty members, and …

The ubiquitin-proteasome system (UPS) is involved in the replication of a broad range of
viruses. Since replication of the murine hepatitis virus (MHV) is impaired upon proteasomal …

Prion diseases are fatal, neurodegenerative disorders in humans and animals and are
characterized by the accumulation of an abnormally folded isoform of the cellular prion …

Over the last 30 years, many drugs have been tested both in cell culture and in vivo for their
ability to prevent the generation of prions and the development of transmissible spongiform …

Exportable proteins that have significant defects in nascent polypeptide folding or subunit
assembly are frequently retained in the endoplasmic reticulum and subject to endoplasmic …