Pathological self-assembly is a concept that is classically associated with amyloids, such as
amyloid-β (Aβ) in Alzheimer's disease and α-synuclein in Parkinson's disease. In prokaryotic …

This focus review describes the development of stimuli-responsive supramolecular systems,
emphasizing molecular design approach used to construct constituent molecular hybrids …

Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis and
vasculopathy. CXCL4 represents an early serum biomarker of severe SSc and likely …

Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of
potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA …

Defense of the central nervous system (CNS) against infection must be accomplished
without generation of potentially injurious immune cell-mediated or off-target inflammation …

Multifunctional proteins are evolutionary puzzles: how do proteins evolve to satisfy multiple
functional constraints? S100A9 is one such multifunctional protein. It potently amplifies …

Antimicrobial peptides (AMPs) collectively constitute a key component of the host innate
immune system. They span a diverse space of sequences and can be α-helical, β-sheet, or …

Antifungal peptides are promising drug candidates to fight fungal infections in the clinics and
agriculture. However, recent data suggest that antifungal peptides might also play a role …

Antimicrobial peptides are ubiquitous across all life forms and they often serve as a first line
of defense, protecting their host organisms from predators, intruders, or nutritional …

Many questions remain regarding the molecular mechanisms by which proteins evolve new
properties and functions. How do proteins evolve new functions without perturbing existing …