Understanding the diversity of dynamic structures and functions of DNA and RNA in biology
requires tools that can selectively and intimately probe these biomolecules. Synthetic …

The breadth of structure and function displayed by the molecules of biology is remarkable.
Considering that there are only three major biopolymer backbones (proteins, ribonucleic …

Fluorescence spectroscopy, one of the most informative and sensitive analytical techniques,
has played and continues to play key roles in modern research. Indeed, unraveling the inner …

Faithful maintenance of the genome is crucial to the individual and to species. DNA damage
arises from both endogenous sources such as water and oxygen and exogenous sources …

▪ Abstract DNA replication fidelity is a key determinant of genome stability and is central to
the evolution of species and to the origins of human diseases. Here we review our current …

Compositions and methods for nucleic acid sequencing include template constructs that
comprise double stranded portions in a partially or completely contiguous constructs, to …

▪ Abstract Understanding the mechanisms by which genetic information is replicated is
important both to basic knowledge of biological organisms and to many useful applications …

While natural and synthetic N-nucleosides are vulnerable to enzymatic and acid-catalyzed
hydrolysis of the nucleosidic bond, their C-analogues are much more stable. Several C …

1. INTRODUCTION: GOALS OF MULTICHROMOPHORE STUDIES Multichromophoric
systems have gained intense interest in recent decades. 1 The arraying of chromophores at …

A set of eight methionine analogues was assayed for translational activity in Escherichia
coli. Norvaline and norleucine, which are commercially available, were assayed along with …