A key regulator of proliferation, differentiation and cell fate, the c-Myb transcription factor
regulates the expression of hundreds of genes and is in turn regulated by numerous …

The main goal of regenerative medicine is to replace damaged tissue. To do this it is
necessary to understand in detail the whole regeneration process including differentiated …

Proinflammatory macrophage (M1) is now being suggested as a potential therapeutic
strategy for cancer because of its tumoricidal capacity. However, few studies have been …

Osteoarthritis is a debilitating joint disease that is characterized by pathologic changes in
both cartilage and bone, potentially involving cross talk between these tissues that is …

The generation of induced pluripotent stem (iPS) cells from somatic cells by the ectopic
expression of defined transcription factors has provided the regenerative medicine field with …

Mesenchymal progenitor cells (MPCs) are nonhematopoietic multipotent cells capable of
differentiating into mesenchymal and nonmesenchymal lineages. While they can be isolated …

Immunotherapy has become an indispensable part of the comprehensive treatment of
hepatocellular carcinoma (HCC). Immunotherapy has proven effective in patients with early …

Since the successful isolation, characterization and long-term culture of embryonic stem
cells (ESCs) from mice in the early 1980s and from humans a decade later, considerable …

Nearly two decades of research in regenerative medicine have been focused on the
development of stem cells as a therapeutic option for treatment of the ischemic heart. Given …

Classical non-viral methods of gene transfer, such as chemical transfection, have met with
limited success of instillation of genetic material into non-proliferating cells in vitro. Among …