Correlated variability in cortical activity is ubiquitously quenched following stimulus onset, in
a stimulus-dependent manner. These modulations have been attributed to circuit dynamics …

Mouse primary somatosensory barrel cortex (wS1) processes whisker sensory information,
receiving input from two distinct thalamic nuclei. The first-order ventral posterior medial …

After half a century of research, the sensory features coded by neurons of the rodent barrel
cortex remain poorly understood. Still, views of the sensory representation of whisker …

Cortical networks exhibit intrinsic dynamics that drive coordinated, large-scale fluctuations
across neuronal populations and create noise correlations that impact sensory coding. To …

Models of cortical dynamics often assume a homogeneous connectivity structure. However,
we show that heterogeneous input connectivity can prevent the dynamic balance between …

High-level information processing in the mammalian cortex requires both segregated
processing in specialized circuits and integration across multiple circuits. One possible way …

To further advance functional MRI (fMRI)–based brain science, it is critical to dissect fMRI
activity at the circuit level. To achieve this goal, we combined brain-wide fMRI with neuronal …

Single cell intracellular recordings in-vivo at deep brain structures are seldomly
accompanied by nearby optogenetics or drug application. The use of such tools is limited as …

Pyramidal tract neurons (PTs) represent the major output cell type of the mammalian
neocortex. Here, we report the origins of the PTs' ability to respond to a broad range of …

Processing of sensory information in neural circuits is modulated by an animal's behavioral
state, but the underlying cellular mechanisms are not well understood. Focusing on the …