Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …

Patients with diabetes mellitus have> 2× the risk for develo** heart failure (HF; HF with
reduced ejection fraction and HF with preserved ejection fraction). Cardiovascular …

The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …

Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …

To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

Heart failure is one of the leading causes of death worldwide and has been singled out as
an emerging epidemic. 1, 2 With a 5-year survival rate of 50%, heart failure poses a …

Metabolic pathways integrate to support tissue homeostasis and to prompt changes in cell
phenotype. In particular, the heart consumes relatively large amounts of substrate not only to …