Systemic autoinflammatory diseases (SAIDs) are a heterogeneous group of disorders
caused by excess activation of the innate immune system in an antigen-independent …

Dysregulation and hyperactivation of innate immune responses can lead to the onset of
systemic autoinflammatory diseases. Monogenic autoinflammatory diseases are caused by …

The atypical protein kinase ALPK1 is activated by the bacterial nucleotide sugar ADP-
heptose and phosphorylates TIFA to switch on a signaling pathway that combats microbial …

Purpose We aimed to characterize the ocular phenotype of patients with ROSAH (retinal
dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome and …

Introduction The symptom of dry mouth has multiple potential etiologies and can be a
diagnostic clue to the presence of common systemic diseases encountered in rheumatology …

Introduction Childhood uveitis is a sight-threatening condition, because if not properly
recognized and treated can lead to several ocular complications and blindness. It represents …

Ever since the first description of an inherited immunodeficiency in 1952 in a boy with
gammaglobulin deficiency, new insights have progressed rapidly in disorders that are now …

M1 macrophage polarization and synovitis play an important role in the pathogenesis of
temporomandibular joint osteoarthritis (TMJOA). Reduced molecular weight of hyaluronic …

Objective: Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the
rectum and colon with unknown etiology. A growing number of evidence suggest that the …

Retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis and migraine headache
(ROSAH) syndrome is an autosomal dominant disorder and to date is known to be caused …