Functional foods particularly prebiotics and probiotics have attracted a lot of attention due to
their ability to alter gut microbiota and have an impact on a number of health and disease …

Methods: We used data from the Alberta Congenital Anomalies Surveillance System
(ACASS) to calculate the prevalence and perform chi-square linear trend analyses. Results …

Background: Several studies have reported conflicting results on the association between
maternal exposure to folic acid (FA) and/or multivitamin (MV) supplements and the risk of …

Pleiotropy is defined as the phenomenon of a single gene locus influencing two or more
distinct phenotypic traits. However, nicotinamide adenine dinucleotide (NAD+) deficiency …

Introduction: In the early stage of embryonic development, the neural tube (NT) cannot be
closed properly due to some complex factors, including environmental factors, genetic …

Introduction The association between extreme ambient heat exposures during pregnancy
and neural tube defects (NTDs) in offspring remains unclear. This study sought to estimate …

Background Nicotinamide adenine dinucleotide (NAD+) depletion is associated with
numerous diseases in humans. Recently it was revealed that genetic blockage of the NAD+ …

Open dysraphisms, that is, myelomeningocele and myeloschisis, are rare diseases
associated with a risk of severe disability, including lower limb motor and sensory deficiency …

Chromosomal aneuploidies, microduplications and microdeletions are the most common
confirmed genetic causes of spina bifida. Microduplications of Xq27 containing the SOX3 …

Abstract Background & Aims Folate is crucial for the development of the fetal neurological
system. Moroccan Health authorities promote Folic acid (FA) supplementation, before and …