Nanostructured lipid carrier–based gel for repurposing simvastatin in localized treatment of breast cancer: formulation design, development, and in vitro and in vivo …

PS Kumbhar, AS Manjappa, RR Shah, SJ Nadaf… - AAPS …, 2023 - Springer
Simvastatin (SMV) is noticed as a repurposed candidate to be effective against breast
cancer (BC). However, poor solubility, dose-limiting toxicities, and side effects are critical …

Development, optimization, and evaluation of Empagliflozin nanoemulsion for the management of neuroinflammation associated Alzheimer's disease

NA Alhakamy, EA Aljehani, AB Abdel-Naim… - Journal of Drug Delivery …, 2024 - Elsevier
Alzheimer's disease (AD) is one of the most pervasive and progressive neurodegenerative
disorders. Recently, empagliflozin (EMPA) has been reported as a potent anti-inflammatory …

QbD and Six Sigma quality approach for chromatographic estimation of repurposed simvastatin from nanostructured lipid carriers

P Kumbhar, P Waghmare, S Nadaf, A Manjappa… - Microchemical …, 2023 - Elsevier
The present research aimed to develop a simple, rapid, and sensitive RP-HPLC method for
the estimation of repurposed simvastatin (SMV) from nanostructured lipid carriers (NLCs) …

Tadalafil nanoemulsion mists for treatment of pediatric pulmonary hypertension via nebulization

B Elbardisy, N Boraie, S Galal - Pharmaceutics, 2022 - mdpi.com
Oral tadalafil (TD) proved promising in treating pediatric pulmonary arterial hypertension
(PAH). However, to ensure higher efficacy and reduce the systemic side effects, targeted …

Nanoemulsion drug delivery system loaded with imiquimod: a QbD-based strategy for augmenting anti-cancer effects

ST Jadhav, VR Salunkhe, SD Bhinge - Future Journal of Pharmaceutical …, 2023 - Springer
Background Skin cancer is becoming a public health concern due to increased exposure to
environmental pollutants and UV rays, among other factors. In India, skin neoplasms …

Palbociclib-letrozole loaded solid self-nano emulsifying drug delivery system for oral treatment of breast cancer: In-vitro and In-vivo characterization

ST Galatage, AS Manjappa, A Salawi, JL Desai… - Journal of Drug Delivery …, 2025 - Elsevier
The current research aimed to formulate a self-nanoemulsifying drug delivery system
(SNEDDS) co-loaded with palbociclib (PCB) and letrozole (LTZ) to enhance anticancer …

Dalit movements and the search for identity.

G Shah - 1990 - cabidigitallibrary.org
Dalit means poor, oppressed persons in many Indian languages. However, the dalit
movement originated from the neo-Buddhist followers of Babasahib Ambedkar in the 1970s …

Revolutionizing nanomedicine: Expanding horizons of nanoemulsions in drug delivery and beyond

M Kumar, N Chauhan, D Kumar… - Journal of Dispersion …, 2024 - Taylor & Francis
Nanoemulsions are nano-sized particles, typically ranging from tens to hundreds of
nanometers. These nanoemulsions possess various appealing properties, making them …

Concurrent oral delivery of non-oncology drugs through solid self-emulsifying system for repurposing in hepatocellular carcinoma

RM Ardad, AS Manjappa, SC Dhawale… - Drug Development …, 2023 - Taylor & Francis
Objective The present study aimed to identify a safe and effective non-oncology drug
cocktail as an alternative to toxic chemotherapeutics for hepatocellular carcinoma (HCC) …

[PDF][PDF] Tadalafil Nanoemulsion Mists for Treatment of Pediatric Pulmonary Hypertension via Nebulization. Pharmaceutics 2022, 14, 2717

B Elbardisy, N Boraie, S Galal - 2022 - leopard.tu-braunschweig.de
Oral tadalafil (TD) proved promising in treating pediatric pulmonary arterial hypertension
(PAH). However, to ensure higher efficacy and reduce the systemic side effects, targeted …