[HTML][HTML] Candida glabrata hospital isolate from Lebanon reveals micafungin resistance associated with increased chitin and resistance to a cell-surface-disrupting …

N Fattouh, RA Khalaf, R Husni - Journal of global antimicrobial resistance, 2024 - Elsevier
Objectives This study aimed to identify the resistance mechanisms to micafungin and
fluconazole in a clinical isolate of Candida glabrata. Methods The isolate was whole …

Phenotypic and genotypic characterization of Candida parapsilosis complex isolates from a Lebanese hospital

R El Hady, N Fattouh, M Finianos, I Bitar, T Fakih… - Scientific Reports, 2025 - nature.com
The opportunistic pathogen Candida parapsilosis is a major causative agent of candidiasis
leading to death in immunocompromised individuals. Azoles are the first line of defense in …

Systematic Review of the Presentation, Treatment, and Outcome of Chronic Disseminated Candidiasis in Children with Cancer or Following Hematopoietic Cell …

E Eagling‐Every, SK Tsoi, H Walker… - Pediatric Blood & …, 2025 - Wiley Online Library
Chronic disseminated candidiasis (CDC) is a rare complication of immunosuppression. This
review describes the presentation, management, and outcomes of CDC in pediatric patients …

[HTML][HTML] Antifungal Use and Resistance in a Lower–Middle-Income Country: The Case of Lebanon

N Hassoun, II Kassem, M Hamze, J El Tom, N Papon… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance is a serious threat, particularly in low-and middle-income countries
(LMICs). Antifungal resistance is often underestimated in both healthcare and non-clinical …

Adhesive and biofilm‐forming Candida glabrata Lebanese hospital isolates harbour mutations in subtelomeric silencers and adhesins

N Fattouh, R Husni, M Finianos, I Bitar, RA Khalaf - Mycoses, 2024 - Wiley Online Library
Abstract Background The prevalence of Candida glabrata healthcare‐associated infections
is on the rise worldwide and in Lebanon, Candida glabrata infections are difficult to treat as …

Candida glabrata maintains two HAP1 ohnologs, HAP1A and HAP1B, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and …

D Saha, JB Gregor, S Hoda, KE Eastman… - Msphere, 2024 - journals.asm.org
Candida glabrata exhibits innate resistance to azole antifungal drugs but also has the
propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is …

[PDF][PDF] Biofilm Formation and Antifungal Susceptibility Profile of Candida Species Responsible for Vulvovaginal Candidiasis in Pregnant and Non-Pregnant Women …

R Rachel, M Anuradha… - Journal of Pure & …, 2024 - pdfs.semanticscholar.org
Most bacteria and fungi are capable of producing biofilms, enabling them to thrive in nature
on distinct surfaces. Biofilm formation stands out as one of the most prominent virulence …

Transcription factor Hap2p regulates antioxidant stress responses to maintain miconazole resistance in Candida albicans

Y Qin, Q Lv, H Xu, Y Cao, B Han - Mycology, 2025 - Taylor & Francis
Acquired resistance in Candida albicans brings about a serious challenge to the clinical
application of azoles, so it is urgent to elucidate the mechanisms of azole resistance to …

Nineteen years retrospective analysis of epidemiology, antifungal resistance and a nomogram model for 30-day mortality in nosocomial candidemia patients

Z Dai, X Lan, M Cai, Y Liao, J Zhang, N Ye… - Frontiers in Cellular …, 2025 - frontiersin.org
Background The incidence of nosocomial candidemia has increased in recently years,
however, the epidemiological data remain insufficient in China. Methods A total of 234 …

Candida glabrata maintains two Hap1 homologs, Zcf27 and Zcf4, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and …

D Saha, JB Gregor, S Hoda, KE Eastman… - …, 2024 - pmc.ncbi.nlm.nih.gov
Candida glabrata exhibits innate resistance to azole antifungal drugs but also has the
propensity to rapidly develop clinical drug resistance. Azole drugs, which target Erg11, is …