The mitochondrial electron transport chain (ETC) enables essential metabolic reactions;
nonetheless, the cellular responses to defects in mitochondria and the modulation of …

During development cells become restricted in their differentiation potential by repressing
alternative cell fates, and the Polycomb complex plays a crucial role in this process …

The niche critically controls stem cell behavior, but its regulatory input at the whole-genome
level is poorly understood. We elucidated transcriptional programs of the somatic and …

The evolutionarily conserved Hox genes define segment identities along the anterior-
posterior axis and are expressed in most cell types within each segment, performing specific …

Gene regulation depends on the interaction between chromatin-associated factors, such as
transcription factors (TFs), which promote chromatin loops to ensure tight contact between …

Transcription factor (TF) networks define the precise development of multicellular organisms.
While many studies focused on TFs expressed in specific cell types to elucidate their …