Since the discovery of SNARE proteins in the late 1980s, SNAREs have been recognized as
key components of protein complexes that drive membrane fusion. Despite considerable …

The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a
wide array of signaling events, leading to protective (eg, cytoskeletal rearrangement) and …

The molecular mechanisms controlling synaptogenesis in the central nervous system (CNS)
are poorly understood. Previous reports showed that a glia-derived factor strongly promotes …

Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Membrane fusion, one of the most fundamental processes in life, occurs when two separate
lipid membranes merge into a single continuous bilayer. Fusion reactions share common …

Lysosomal storage diseases are a group of metabolic disorders caused by deficiencies of
several components of lysosomal function. Most commonly affected are lysosomal …

▪ Abstract Lipid raft microdomains were conceived as part of a mechanism for the
intracellular trafficking of lipids and lipid-anchored proteins. The raft hypothesis is based on …

Key events in cellular trafficking occur at the cell surface, and it is desirable to visualize
these events without interference from other regions deeper within. This review describes a …

Cholesterol modulates the bilayer structure of biological membranes in multiple ways. It
changes the fluidity, thickness, compressibility, water penetration and intrinsic curvature of …

Membrane fusion is a key process in all living organisms that contributes to a variety of
biological processes including viral infection, cell fertilization, as well as intracellular …