Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of
cancer-related death worldwide. Countless CRC patients undergo disease progression. As …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Photodynamic therapy (PDT) has aroused great research interest in recent years owing to its
high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity. However …

Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for
adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …

Solid tumors have developed robust ferroptosis resistance. The mechanism underlying
ferroptosis resistance regulation in solid tumors, however, remains elusive. Here, we report …

Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Tumor angiogenesis is necessary for the continued survival and development of tumor cells,
and plays an important role in their growth, invasion, and metastasis. The tumor …