Designer drugs: mechanism of action and adverse effects

D Luethi, ME Liechti - Archives of toxicology, 2020 - Springer
Psychoactive substances with chemical structures or pharmacological profiles that are
similar to traditional drugs of abuse continue to emerge on the recreational drug market …

An update on the implications of new psychoactive substances in public health

AY Simão, M Antunes, E Cabral, P Oliveira… - International journal of …, 2022 - mdpi.com
The emergence of new psychoactive substances has earned a great deal of attention, and
several reports of acute poisoning and deaths have been issued involving, for instance …

Neurochemical models of near-death experiences: A large-scale study based on the semantic similarity of written reports

C Martial, H Cassol, V Charland-Verville… - Consciousness and …, 2019 - Elsevier
The real or perceived proximity to death often results in a non-ordinary state of
consciousness characterized by phenomenological features such as the perception of …

Characterization of 3-Hydroxyeticyclidine (3-HO-PCE) metabolism in human liver microsomes and biological samples using high-resolution mass spectrometry

IA Larabi, D Joseph, C Lesueur, JC Alvarez - Metabolites, 2023 - mdpi.com
3-Hydroxyeticyclidine (3-HO-PCE) is a ketamine derivative that produces dissociative,
hallucinogenic, and euphoric effects when consumed, but little is known about its …

1, 2-Diarylethylamine-and ketamine-based new psychoactive substances

J Wallach, SD Brandt - New Psychoactive Substances: Pharmacology …, 2018 - Springer
While phencyclidine (PCP) and ketamine remain the most well-studied and widely known
dissociative drugs, a number of other agents have appeared since the late 1950s and early …

Analytical characterization of 3-MeO-PCP and 3-MMC in seized products and biosamples: the role of LC-HRAM-orbitrap-MS and solid deposition GC-FTIR

G Frison, F Zancanaro, S Frasson, L Quadretti… - Frontiers in …, 2021 - frontiersin.org
Among the phencyclidine (PCP) and synthetic cathinone analogs present on the street
market, 3-methoxyphencyclidine (3-MeO-PCP) is one of the most popular dissociative …

Prodrugs of new psychoactive substances (NPS): a new challenge

SP Elliott, T Holdbrook… - Journal of forensic …, 2020 - Wiley Online Library
The concept of a substance acting as a prodrug for an intended drug is not new and has
been known and utilized with particular benefits within medicine for efficacy and patient …

3-Methoxy-Phencyclidine Induced Psychotic Disorder: A Literature Review and an 18F-FDG PET/CT Case Report

M Pepe, M Di Nicola, F Cocciolillo, S Chiappini… - Pharmaceuticals, 2024 - mdpi.com
New Psychoactive Substances (NPS) are modifying the drug scenario worldwide and have
become a public health concern because of their toxicological profiles and their harmful …

The role of NMDARs in the anesthetic and antidepressant effects of ketamine

L Zhou, J Duan - CNS Neuroscience & Therapeutics, 2024 - Wiley Online Library
Background As a phencyclidine (PCP) analog, ketamine can generate rapid‐onset and
substantial anesthetic effects. Contrary to traditional anesthetics, ketamine is a dissociative …

[HTML][HTML] The dilemma of new psychoactive substances: A growing threat

HS Sajwani - Saudi Pharmaceutical Journal, 2023 - Elsevier
New psychoactive substances (NPS) pose a major public threat and are a growing problem
worldwide. They were designed to replace banned or controlled drugs while esca** …