Xenobiotica-metabolizing enzymes in the lung of experimental animals, man and in human lung models
The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …
Effect of natural polyphenols on CYP metabolism: implications for diseases
EA Korobkova - Chemical research in toxicology, 2015 - ACS Publications
Cytochromes P450 (CYPs) are a large group of hemeproteins located on mitochondrial
membranes or the endoplasmic reticulum. They play a crucial role in the metabolism of …
membranes or the endoplasmic reticulum. They play a crucial role in the metabolism of …
Xenobiotic metabolizing cytochrome P450 in pig, a promising animal model
E Puccinelli, P Giovanni Gervasi… - Current drug …, 2011 - ingentaconnect.com
The pig has been used as an important animal model for human studies because of its
similarity in size, physiology and disease development. However, in contrast to the extensive …
similarity in size, physiology and disease development. However, in contrast to the extensive …
Characterization of porcine hepatic and intestinal drug metabolizing CYP450: comparison with human orthologues from a quantitative, activity and selectivity …
W Schelstraete, LD Clerck, E Govaert, J Millecam… - Scientific Reports, 2019 - nature.com
Over the past two decades, the pig has gained attention as a potential model for human drug
metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation …
metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation …
Flavonoids activate pregnane × receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells
Background The expression of the drug-metabolizing enzyme cytochrome P450 3A4
(CYP3A4) is regulated by the pregnane× receptor (PXR), which is modulated by numerous …
(CYP3A4) is regulated by the pregnane× receptor (PXR), which is modulated by numerous …
[HTML][HTML] Cytochrome P450 enzymes mediated by DNA methylation is involved in deoxynivalenol-induced hepatoxicity in piglets
A Liu, Y Yang, J Guo, Y Gao, Q Wu, L Zhao, L Sun… - Animal Nutrition, 2022 - Elsevier
Deoxynivalenol (DON) is an inevitable contaminant in animal feed and can lead to liver
damage, then decreasing appetite and causing growth retardation in piglets. Although many …
damage, then decreasing appetite and causing growth retardation in piglets. Although many …
The effectiveness of dietary byproduct antioxidants on induced CYP genes expression and histological alteration in piglets liver and kidney fed with aflatoxin B1 and …
The purpose of this study was to investigate the potential of a byproduct mixture derived from
grapeseed and sea buckthorn oil industry to mitigate the harmful damage produced by …
grapeseed and sea buckthorn oil industry to mitigate the harmful damage produced by …
Cytochrome P450 isoforms are differently up-regulated in aflatoxin B1-exposed human lymphocytes and monocytes
Abstract Context: Aflatoxins (AFs) are highly hazardous mycotoxins with potent carcinogenic,
mutagenic and immune disregulatory properties. Cytochrome P450 (CYP) isoforms are …
mutagenic and immune disregulatory properties. Cytochrome P450 (CYP) isoforms are …
The constitutive androstane receptor and pregnane X receptor in the brain
P Torres‐Vergara, YS Ho, F Espinoza… - British journal of …, 2020 - Wiley Online Library
Since their discovery, the orphan nuclear receptors constitutive androstane receptor (CAR;
NR1I3) and pregnane X receptor (PXR; NR1I2) have been regarded as master regulators of …
NR1I3) and pregnane X receptor (PXR; NR1I2) have been regarded as master regulators of …
[HTML][HTML] Regulation of porcine hepatic cytochrome p450—implication for boar taint
MK Rasmussen, G Zamaratskaia - Computational and Structural …, 2014 - Elsevier
Abstract Cytochrome P450 (CYP450) is the major family of enzymes involved in the
metabolism of several xenobiotic and endogenous compounds. Among substrates for …
metabolism of several xenobiotic and endogenous compounds. Among substrates for …