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Integration of Hippo-YAP signaling with metabolism
The Hippo-Yes-associated protein (YAP) signaling network plays a central role as an
integrator of signals that control cellular proliferation and differentiation. The past several …
integrator of signals that control cellular proliferation and differentiation. The past several …
Gut organoids: mini-tissues in culture to study intestinal physiology and disease
In vitro, cell cultures are essential tools in the study of intestinal function and disease. For the
past few decades, monolayer cellular cultures, such as cancer cell lines or immortalized cell …
past few decades, monolayer cellular cultures, such as cancer cell lines or immortalized cell …
The therapeutic effect of SCFA-mediated regulation of the intestinal environment on obesity
Intestinal environment disorder is a potential pathological mechanism of obesity. There is
increasing evidence that disorders in the homeostasis of the intestinal environment can …
increasing evidence that disorders in the homeostasis of the intestinal environment can …
New mechanisms to prevent heart failure with preserved ejection fraction using glucagon-like peptide-1 receptor agonism (GLP-1 RA) in metabolic syndrome and in …
This review examines the impact of obesity on the pathophysiology of heart failure with
preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF …
preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF …
S1PR2/RhoA/ROCK1 pathway promotes inflammatory bowel disease by inducing intestinal vascular endothelial barrier damage and M1 macrophage polarization
X Wang, S Chen, H **ang, X Wang, J **ao… - Biochemical …, 2022 - Elsevier
Vascular and immune dysfunctions are thought to be related to the pathogenesis of
inflammatory bowel disease (IBD), but behind this, the exact mechanism of mucosal …
inflammatory bowel disease (IBD), but behind this, the exact mechanism of mucosal …
What is an L-cell and how do we study the secretory mechanisms of the L-cell?
Synthetic glucagon-like peptide-1 (GLP-1) analogues are effective anti-obesity and anti-
diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and …
diabetes drugs. The beneficial actions of GLP-1 go far beyond insulin secretion and …
L-cell differentiation is induced by bile acids through GPBAR1 and paracrine GLP-1 and serotonin signaling
Glucagon-like peptide 1 (GLP-1) mimetics are effective drugs for treatment of type 2
diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 …
diabetes, and there is consequently extensive interest in increasing endogenous GLP-1 …
Enteroendocrine dynamics–new tools reveal hormonal plasticity in the gut
The recent intersection of enteroendocrine cell biology with single-cell technologies and
novel in vitro model systems has generated a tremendous amount of new data. Here we …
novel in vitro model systems has generated a tremendous amount of new data. Here we …
Curcumin Compensates GLP‐1 Deficiency via the Microbiota‐Bile Acids Axis and Modulation in Functional Crosstalk between TGR5 and FXR in ob/ob Mice
F Tian, T Chen, W Xu, Y Fan, X Feng… - Molecular nutrition & …, 2023 - Wiley Online Library
Scope Glucagon‐like peptide‐1 (GLP‐1) deficiency occurs in obesity‐related pathologies
due to defects in the intestinal lumen. And expanding the L‐cell population has emerged as …
due to defects in the intestinal lumen. And expanding the L‐cell population has emerged as …
[HTML][HTML] Digesting the mechanobiology of the intestinal epithelium
The dizzying life of the homeostatic intestinal epithelium is governed by a complex interplay
between fate, form, force and function. This interplay is beginning to be elucidated thanks to …
between fate, form, force and function. This interplay is beginning to be elucidated thanks to …