Mitochondria are the main source of reactive oxygen species (ROS) in cells. Early studies
have shown that mitochondrial reactive oxygen species (mROS) are related to the …

Mitochondria are quantifiably the most important sources of superoxide (O2●−) and
hydrogen peroxide (H2O2) in mammalian cells. The overproduction of these molecules has …

Reactive Oxygen Species (ROS) can cause oxidative damage and have been proposed to
be the main cause of aging and age-related diseases including cancer, diabetes and …

The brain is the most complex human organ, consuming more energy than any other tissue
in proportion to its size. It relies heavily on mitochondria to produce energy and is made up …

Mitochondrial superoxide production is an important source of reactive oxygen species in
cells, and may cause or contribute to ageing and the diseases of ageing. Seven major sites …

Mitochondrial dysfunction has been proposed to play a pivotal role in neurodegenerative
diseases, including Alzheimer's disease (AD). To address whether mitochondrial …

Mitochondria couple respiration to ATP synthesis through an electrochemical proton
gradient. Proton leak across the inner membrane allows adjustment of the coupling …

Maximum life span differences among animal species exceed life span variation achieved
by experimental manipulation by orders of magnitude. The differences in the characteristic …

Research programmes on oxidative stress and hormesis are wide ranging. Biomedical and
toxicological sciences have traditionally centralised such research, but in the last years we …

Mitochondria are highly dynamic organelles which fulfill a plethora of functions. In addition to
their prominent role in energy metabolism, mitochondria are intimately involved in various …