Latest developments in metal complexes as anticancer agents

R Paprocka, M Wiese-Szadkowska… - Coordination Chemistry …, 2022 - Elsevier
Every year novel biologically active compounds are designed as antitumor agents. This
review covers and highlights some of the most important findings described during 2018 …

Ruthenium complexes as anticancer agents: A brief history and perspectives

SY Lee, CY Kim, TG Nam - Drug design, development and therapy, 2020 - Taylor & Francis
Platinum (Pt)-based anticancer drugs such as cisplatin have been used to treat various
cancers. However, they have some limitations including poor selectivity and toxicity towards …

Synthesis of sorafenib− ruthenium complexes, investigation of biological activities and applications in drug delivery systems as an anticancer agent

B Zengin Kurt, D Öztürk Civelek… - Journal of Medicinal …, 2024 - ACS Publications
Sorafenib, a multiple kinase inhibitor, is widely used as a first-line treatment for
hepatocellular carcinoma. However, there is a need for more effective alternatives when …

Target based chemotherapeutic advancement of ruthenium complexes

BK Kundu, S Mukhopadhyay - Coordination Chemistry Reviews, 2021 - Elsevier
Over the last few years, great emphasis has been given to develop ruthenium complexes to
act as target specified chemotherapeutic agents. Indeed, there are few reviews available …

Metal Complexes in cancer treatment: Journey so far

A Kumar Singh, A Kumar, H Singh… - Chemistry & …, 2023 - Wiley Online Library
Metal complexes in cancer therapy have attracted much interest mainly because metals
exhibit unique characteristics, such as redox activity, metal‐ligand interaction, structure and …

Ruthenium (II)‐Dithiocarbazates as Anticancer Agents: Synthesis, Solution Behavior, and Mitochondria‐Targeted Apoptotic Cell Death

G Sahu, SA Patra, S Lima, S Das… - … A European Journal, 2023 - Wiley Online Library
The reaction of the Ru (PPh3) 3Cl2 with HL1− 3− OH (− OH stands for the oxime hydroxyl
group; HL1− OH= diacetylmonoxime‐S‐benzyldithiocarbazonate; HL2− OH …

[HTML][HTML] Biological properties of ruthenium (II)/(III) complexes with flavonoids as ligands

M Małecka, A Skoczyńska, DM Goodman… - Coordination Chemistry …, 2021 - Elsevier
This review highlights the progress in the development of ruthenium (II)/(III) complexes with
flavone derivatives as potential therapeutic agents. We focused on natural hydroxyflavone …

Metal (triphenylphosphine)-Atovaquone complexes: Synthesis, antimalarial activity, and suppression of heme detoxification

L Daniel, A Karam, CHJ Franco, C Conde… - Inorganic …, 2024 - ACS Publications
To ascertain the bioinorganic chemistry of metals conjugated with quinones, the complexes
[Ag (ATV)(PPh3) 2](1),[Au (ATV)(PPh3)]· 2H2O (2), and [Cu (ATV)(PPh3) 2](3) were …

Synthesis and anticancer mechanisms of zinc (II)-8-hydroxyquinoline complexes with 1, 10-phenanthroline ancillary ligands

LQ Du, TY Zhang, XM Huang, Y Xu, MX Tan… - Dalton …, 2023 - pubs.rsc.org
Twenty new zinc (II) complexes with 8-hydroxyquinoline (H-Q1–H-Q6) in the presence of 1,
10-phenanthroline derivatives (D1–D10) were synthesized and formulated as [Zn (Q1) 2 …

Fluorescent diorganotin (IV) complexes as anticancer agents: study of cytotoxicity, cellular localization, and mechanism of cell death

SA Patra, G Sahu, D Mohapatra, PD Pattanayak… - …, 2023 - ACS Publications
Three luminescent mixed ligand diorganotin (IV) complexes [Sn2Ph4 (L) 1–3 (DPA)(MeOH)
Cl](where L1=(Z)-N-((E)-3-ethoxy-2-hydroxybenzylidene) isonicotinohydrazonic acid, L2=(Z) …