Stable isotope-labeling studies in metabolomics: new insights into structure and dynamics of metabolic networks
The rapid emergence of metabolomics has enabled system-wide measurements of
metabolites in various organisms. However, advances in the mechanistic understanding of …
metabolites in various organisms. However, advances in the mechanistic understanding of …
How to measure metabolic fluxes: a taxonomic guide for 13C fluxomics
Highlights•Tracer experiments, analytics and modeling constitute the 13 C fluxomics
triumvirate.•13 C fluxomics tools differ in complexity, information power and universality.•The …
triumvirate.•13 C fluxomics tools differ in complexity, information power and universality.•The …
The plasticity of cyanobacterial metabolism supports direct CO2 conversion to ethylene
The cyanobacterial tricarboxylic acid (TCA) cycle functions in both in biosynthesis and
energy generation. However, it has until recently been generally considered to be …
energy generation. However, it has until recently been generally considered to be …
Isotopically nonstationary metabolic flux analysis (INST-MFA): putting theory into practice
Typically, 13 C flux analysis relies on assumptions of both metabolic and isotopic steady
state. If metabolism is steady but isotope labeling is not allowed to fully equilibrate …
state. If metabolism is steady but isotope labeling is not allowed to fully equilibrate …
Isotope tracing untargeted metabolomics reveals macrophage polarization-state-specific metabolic coordination across intracellular compartments
We apply stable isotope tracing, mass-spectrometry-based untargeted metabolomics, to
reveal the biochemical space labeled by 13 C-substrates in bone-marrow-derived …
reveal the biochemical space labeled by 13 C-substrates in bone-marrow-derived …
An improved method for extraction of polar and charged metabolites from cyanobacteria
A key requirement for 13C Metabolic flux analysis (13C-MFA), a widely used technique to
estimate intracellular metabolic fluxes, is an efficient method for the extraction of …
estimate intracellular metabolic fluxes, is an efficient method for the extraction of …
Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human disease
MG Badur, CM Metallo - Metabolic engineering, 2018 - Elsevier
Metabolic dysfunction has reemerged as an essential hallmark of tumorigenesis, and
metabolic phenotypes are increasingly being integrated into pre-clinical models of disease …
metabolic phenotypes are increasingly being integrated into pre-clinical models of disease …
Advances in metabolic flux analysis toward genome-scale profiling of higher organisms
Methodological and technological advances have recently paved the way for metabolic flux
profiling in higher organisms, like plants. However, in comparison with omics technologies …
profiling in higher organisms, like plants. However, in comparison with omics technologies …
Isotope-assisted metabolic flux analysis: a powerful technique to gain new insights into the human metabolome in health and disease
Cell metabolism represents the coordinated changes in genes, proteins, and metabolites
that occur in health and disease. The metabolic fluxome, which includes both intracellular …
that occur in health and disease. The metabolic fluxome, which includes both intracellular …
Metabolic Flux Analysis of the Synechocystis sp. PCC 6803 ΔnrtABCD Mutant Reveals a Mechanism for Metabolic Adaptation to Nitrogen-Limited Conditions
Metabolic flux redirection during nitrogen-limited growth was investigated in the
Synechocystis sp. PCC 6803 glucose-tolerant (GT) strain under photoautotrophic conditions …
Synechocystis sp. PCC 6803 glucose-tolerant (GT) strain under photoautotrophic conditions …