ABSTRACT RNA interference (RNAi) provides researchers with a versatile means to
modulate target gene expression. The major forms of RNAi molecules, genome-derived …

N4-acetylcytidine (ac4C) is often considered to be a conservative, chemically modified
nucleoside present on tRNA and rRNA. Recent studies have shown extensive ac4C …

Abstract N 6-methyladenosine (m6A) is the most abundant internal modification on mRNA
which influences most steps of mRNA metabolism and is involved in several biological …

Small-molecule and protein/antibody drugs mainly act on genome-derived proteins to exert
pharmacological effects. RNA based therapies hold the promise to expand the range of …

Motivation RNA modifications play critical roles in a series of cellular and developmental
processes. Knowledge about the distributions of RNA modifications in the transcriptomes …

The cross-talk between stem cells and their microenvironment has been shown to have a
direct impact on stem cells' decisions about proliferation, growth, migration, and …

Epitranscriptomics, also known as “RNA epigenetics”, is a chemical modification for RNA
regulation. Ribonucleic acid (RNA) methylation is considered to be a major discovery …

The field of RNA modifications, so-called epitranscriptomics, has flourished over the past
years owing to improvements of detection methods and the identification of important …

In contrast to the amazing exponential growth in knowledge related to long non-coding
RNAs (lncRNAs) involved in cell homeostasis or dysregulated pathological states, little is …

During the last five years, there has been a significantly increasing interest in adult adipose
stem cells (ASCs) as a suitable tool for translational medicine applications. The abundant …