Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

While a variety of factors act to trigger or initiate autoimmune diseases, the process of
epitope spreading is an important contributor in their development. Epitope spreading is a …

The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but
formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …

Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1% of the
world population and is a significant cause of worldwide disability. Though prior studies …

Rheumatoid arthritis (RA) is characterized by synovial joint inflammation and by
development of pathogenic humoral and cellular autoimmunity to citrullinated proteins …

Background Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the
development of rheumatoid arthritis (RA). Objective To investigate whether the recognition of …

Rheumatoid arthritis is associated with the development of autoantibodies to citrullinated
self-proteins. Citrullinated synovial proteins, which are generated via the actions of the …

Neutrophil extracellular traps are associated with a unique form of cell death distinct from
apoptosis or necrosis, whereby invading microbes are trapped and killed. Neutrophil …

Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disorder characterized by
synovitis that leads to cartilage and bone erosion by invading fibrovascular tissue. Mouse …

Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis
(RA). However, their biological role in disease development is still unclear. To obtain insight …