APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019 - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

Clinical applications of chemical exchange saturation transfer (CEST) MRI

KM Jones, AC Pollard, MD Pagel - Journal of Magnetic …, 2018 - Wiley Online Library
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has
been developed and employed in multiple clinical imaging research centers worldwide …

Imaging tumor acidosis: a survey of the available techniques for map** in vivo tumor pH

A Anemone, L Consolino, F Arena, M Capozza… - Cancer and Metastasis …, 2019 - Springer
Cancer cells are characterized by a metabolic shift in cellular energy production,
orchestrated by the transcription factor HIF-1α, from mitochondrial oxidative phosphorylation …

Polymers and organic materials-based pH sensors for healthcare applications

AU Alam, Y Qin, S Nambiar, JTW Yeow… - Progress in Materials …, 2018 - Elsevier
In this review, we discuss chemical, physical and electrochemical properties of pH-sensitive
polymers and organic materials and their sensing mechanisms for healthcare applications …

In Vivo Imaging of Tumor Metabolism and Acidosis by Combining PET and MRI-CEST pH Imaging

DL Longo, A Bartoli, L Consolino, P Bardini, F Arena… - Cancer research, 2016 - AACR
The vast majority of cancers exhibit increased glucose uptake and glycolysis regardless of
oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that …

A General MRI-CEST Ratiometric Approach for pH Imaging: Demonstration of in Vivo pH Map** with Iobitridol

DL Longo, PZ Sun, L Consolino… - Journal of the …, 2014 - ACS Publications
Chemical exchange saturation transfer (CEST) is a novel contrast mechanism for magnetic
resonance imaging (MRI). CEST MRI selectively saturates exchangeable protons that are …

Recent advances in wearable potentiometric pH sensors

Y Tang, L Zhong, W Wang, Y He, T Han, L Xu, X Mo… - Membranes, 2022 - mdpi.com
Wearable sensors reflect the real–time physiological information and health status of
individuals by continuously monitoring biochemical markers in biological fluids, including …

Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF)

O Cohen, S Huang, MT McMahon… - Magnetic resonance …, 2018 - Wiley Online Library
Purpose To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative
chemical exchange saturation transfer (CEST) imaging. Methods We implemented a CEST …

Mechanisms of small heat shock proteins

MK Janowska, HER Baughman… - Cold Spring …, 2019 - cshperspectives.cshlp.org
Small heat shock proteins (sHSPs) are ATP-independent chaperones that delay formation of
harmful protein aggregates. sHSPs' role in protein homeostasis has been appreciated for …

Tunable surface charge enables the electrostatic adsorption-controlled release of neuroprotective peptides from a hydrogel–nanoparticle drug delivery system

E Ho, Y Deng, D Akbar, K Da… - … Applied Materials & …, 2022 - ACS Publications
We exploit the electrostatic interactions between the positively charged neuroprotective
peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), and negatively charged …