The evolution of cancer treatment has provided increasingly targeted strategies both in the
upfront and relapsed disease settings. Small‐molecule inhibitors and immunotherapy have …

Degron tagging allows proteins of interest to be rapidly degraded, in a reversible and
tuneable manner, in response to a chemical stimulus. This provides numerous opportunities …

Small molecules promoting protein–protein interactions produce a range of therapeutic
outcomes. Molecular glue degraders exemplify this concept due to their compact drug-like …

Acute protein knockdown is a powerful approach to dissecting protein function in dynamic
cellular processes. We previously reported an improved auxin-inducible degron system …

The CRL4CRBN ubiquitin ligase is leveraged by molecular glue degraders, small molecules
that reprogram ligase specificity to induce degradation of clinically relevant neosubstrate …

Degradation tags, otherwise known as degrons, are portable sequences that can be used to
alter protein stability. Here, we report that degron-tagged proteins compete for cellular …

Molecular glue (MG) degraders include plant hormones and therapeutic drugs and have
become a hot topic in drug discovery. Unlike bivalent proteolysis targeting chimeras …

Targeted protein degradation (TPD) technologies leveraging the ubiquitin-proteasome
system address" undruggable" proteins but struggle with optimizing targeting warheads and …

G protein-coupled receptors (GPCRs) comprise a family of heptahelical membrane proteins
that mediate intra-and inter-cellular transmembrane signaling. Defects in GPCR signaling …

Chemical inducers of proximity (CIPs) stabilize biomolecular interactions, often causing a
privileged rewiring of cellular biochemistry. While rational design strategies can expedite the …