How environmental nutrient availability impacts T cell metabolism and function remains
poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) …

CO2 release in the light (RL) and its presumed source, oxidative pentose phosphate
pathways, were found to be insensitive to CO2 concentration. The oxidative pentose …

Consumption of fructose has risen markedly in recent decades owing to the use of sucrose
and high-fructose corn syrup in beverages and processed foods, and this has contributed to …

T cells are integral players in the adaptive immune system that readily adapt their
metabolism to meet their energetic and biosynthetic needs. A major hurdle to understand …

Daylength, a seasonal and latitudinal variable, exerts a substantial impact on plant growth.
However, the relationship between daylength and growth is nonproportional, suggesting the …

Cancer cells rewire metabolism to favour the generation of specialized metabolites that
support tumour growth and reshape the tumour microenvironment,. Lysine functions as a …

Pancreatic ductal adenocarcinoma (PDA) has a poor prognosis, and new strategies for
prevention and treatment are urgently needed. We previously reported that histone H4 …

The metabolite acetyl-CoA is necessary for both lipid synthesis in the cytosol and histone
acetylation in the nucleus. The two canonical precursors to acetyl-CoA in the nuclear …

Emerging evidence suggests that epigenetic regulation is dependent on metabolic state,
and implicates specific metabolic factors in neural functions that drive behaviour. In neurons …

Macrophages enforce antitumor immunity by engulfing and killing tumor cells. Although
these functions are determined by a balance of stimulatory and inhibitory signals, the role of …