Encouraging an excitable brain state: mechanisms of brain repair in stroke

MT Joy, ST Carmichael - Nature Reviews Neuroscience, 2021 - nature.com
Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the
sprouting of new axons, the formation of new synapses and the remap** of sensory-motor …

The role of gut microbiota in an ischemic stroke

R Pluta, S Januszewski, SJ Czuczwar - International journal of molecular …, 2021 - mdpi.com
The intestinal microbiome, the largest reservoir of microorganisms in the human body, plays
an important role in neurological development and aging as well as in brain disorders such …

Minocycline promotes functional recovery in ischemic stroke by modulating microglia polarization through STAT1/STAT6 pathways

Y Lu, M Zhou, Y Li, Y Li, Y Hua, Y Fan - Biochemical pharmacology, 2021 - Elsevier
Background Increasing evidence suggests that microglia experience two distinct
phenotypes after acute ischemic stroke (AIS): a deleterious M1 phenotype and a …

Ferroptosis contributes to hypoxic–ischemic brain injury in neonatal rats: Role of the SIRT1/Nrf2/GPx4 signaling pathway

C Li, Z Wu, H Xue, Q Gao, Y Zhang… - CNS neuroscience & …, 2022 - Wiley Online Library
Aims Hypoxic–ischemic brain injury (HIBI) often results in cognitive impairments. Herein, we
investigated the roles of ferroptosis in HIBI and the underlying signaling pathways. Methods …

Neuroplasticity of acupuncture for stroke: An evidence‐based review of MRI

J Zhang, C Lu, X Wu, D Nie, H Yu - Neural Plasticity, 2021 - Wiley Online Library
Acupuncture is widely recognized as a potentially effective treatment for stroke rehabilitation.
Researchers in this area are actively investigating its therapeutic mechanisms. Magnetic …

Improving Outcomes After Post–Cardiac Arrest Brain Injury: A Scientific Statement From the International Liaison Committee on Resuscitation

GD Perkins, R Neumar, CH Hsu, KG Hirsch… - Circulation, 2024 - ahajournals.org
This scientific statement presents a conceptual framework for the pathophysiology of post–
cardiac arrest brain injury, explores reasons for previous failure to translate preclinical data …

Endothelial peroxiredoxin-4 is indispensable for blood–brain barrier integrity and long-term functional recovery after ischemic stroke

N Xu, X Jiang, W Zhang, Y Shi… - Proceedings of the …, 2024 - National Acad Sciences
The endothelial lining of cerebral microvessels is damaged relatively early after cerebral
ischemia/reperfusion (I/R) injury and mediates blood–brain barrier (BBB) disruption …

Restoring after central nervous system injuries: neural mechanisms and translational applications of motor recovery

Z Gao, Z Pang, Y Chen, G Lei, S Zhu, G Li, Y Shen… - Neuroscience …, 2022 - Springer
Central nervous system (CNS) injuries, including stroke, traumatic brain injury, and spinal
cord injury, are leading causes of long-term disability. It is estimated that more than half of …

Guhong injection promotes post-stroke functional recovery via attenuating cortical inflammation and apoptosis in subacute stage of ischemic stroke

Y Wang, H Wu, Z Han, H Sheng, Y Wu, Y Wang, X Guo… - Phytomedicine, 2022 - Elsevier
Background As a leading cause of death and disability, alternative therapies for stroke are
still limited by its complicated pathophysiological manifestations. Guhong injection (GHI) …

Alterations in the gut microbiome with hemorrhagic transformation in experimental stroke

Q Huang, L Di, F Yu, X Feng, Z Liu… - CNS Neuroscience …, 2022 - Wiley Online Library
Objective Hemorrhagic transformation (HT) is a life‐threatening complication of stroke.
Whether changes in gut microbial composition underlie the development of HT remains …