miRNAs: potential as biomarkers and therapeutic targets for cancer

A Chakrabortty, DJ Patton, BF Smith, P Agarwal - Genes, 2023 - mdpi.com
MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules that regulate gene
expression post-transcriptionally by binding to messenger RNAs. miRNAs are important …

Epigenetics of colorectal cancer: biomarker and therapeutic potential

G Jung, E Hernández-Illán, L Moreira… - Nature reviews …, 2020 - nature.com
Colorectal cancer (CRC), a leading cause of cancer-related death worldwide, evolves as a
result of the stepwise accumulation of a series of genetic and epigenetic alterations in the …

[HTML][HTML] From molecular mechanisms to therapeutics: understanding MicroRNA-21 in cancer

J Rhim, W Baek, Y Seo, JH Kim - Cells, 2022 - mdpi.com
MicroRNAs (miRNAs) are small noncoding RNAs that play an important role in regulating
gene expression at a posttranscriptional level. As one of the first discovered oncogenic …

Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies

A Zhao, H Zhou, J Yang, M Li, T Niu - Signal transduction and targeted …, 2023 - nature.com
Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

ncRNA-encoded peptides or proteins and cancer

J Wang, S Zhu, N Meng, Y He, R Lu, GR Yan - Molecular Therapy, 2019 - cell.com
Non-coding RNAs (ncRNAs) are unique RNA transcripts that have been widely identified in
the eukaryotic genome and have been shown to play key roles in the development of many …

Epigenetic alterations in colorectal cancer: emerging biomarkers

Y Okugawa, WM Grady, A Goel - Gastroenterology, 2015 - Elsevier
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. One of the
fundamental processes driving the initiation and progression of CRC is the accumulation of …

PBMDA: A novel and effective path-based computational model for miRNA-disease association prediction

ZH You, ZA Huang, Z Zhu, GY Yan, ZW Li… - PLoS computational …, 2017 - journals.plos.org
In the recent few years, an increasing number of studies have shown that microRNAs
(miRNAs) play critical roles in many fundamental and important biological processes. As …

Genetics and genetic biomarkers in sporadic colorectal cancer

JM Carethers, BH Jung - Gastroenterology, 2015 - Elsevier
Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …

MicroRNA and cancer–a brief overview

M Acunzo, G Romano, D Wernicke… - Advances in biological …, 2015 - Elsevier
MicroRNAs (miRNAs) are short non-coding RNAs with a length of∼ 22 nucleotides,
involved in posttranscriptional regulation of gene expression. Until now, over 2588 miRNAs …

Role of microRNAs in translation regulation and cancer

S Oliveto, M Mancino, N Manfrini… - World journal of …, 2017 - pmc.ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are pervasively expressed and regulate most biological functions.
They function by modulating transcriptional and translational programs and therefore they …