Malaria is among the most devastating and widespread tropical parasitic diseases in which
most prevalent in develo** countries. Antimalarial drug resistance is the ability of a …

In the past few years, using microwave energy to heat and drive chemical reactions has
become increasingly popular in the medicinal chemistry community. First described 20 years …

The completion of the Plasmodium falciparum clone 3D7 genome provides a basis on which
to conduct comparative proteomics studies of this human pathogen. Here, we applied a high …

The artemisinin (ART)-based antimalarials have contributed significantly to reducing global
malaria deaths over the past decade, but we still do not know how they kill parasites. To gain …

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as
drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins …

Approximately 40% of the world population live in areas with the risk of malaria. Each year,
300–500 million people suffer from acute malaria, and 0.5–2.5 million die from the disease …

The last general review of the aspartic peptidase family was by David R. Davies in 1990. 1
Since then, several reviews on selected aspects of the structure and function of aspartic …

Degradation of host hemoglobin by the human malaria parasite Plasmodium falciparum is a
massive metabolic process. What role this degradation plays and whether it is essential for …

The Plasmodium falciparum chloroquine resistance transporter (PfCRT) is a key contributor
to multidrug resistance and is also essential for the survival of the malaria parasite, yet its …

New drugs against malaria are greatly needed. Many approaches to antimalarial drug
discovery are available. These approaches must take into account specific concerns, in …