Diabetes mellitus (DM), an increasing health problem worldwide, is associated with severe
cardiovascular complications. To date, the beneficial effects of physical activity in both …

Background Periodontitis significantly increases the risk of diabetic complications. This
clinical trial investigated the effects of periodontal therapy on cardiac function in patients with …

Left ventricular diastolic dysfunction (LVDD) plays a central role in the pathophysiology of
heart failure with preserved ejection fraction (HFpEF), a major manifestation of heart failure …

Aims Reactive oxygen species are reportedly involved in the mechanism underlying heart
failure with preserved ejection fraction (HFpEF); however, the disease pathophysiology …

Aims: Aerobic exercise improves vascular endothelial function in people with Type 2
diabetes mellitus (T2DM). There is minimal information available regarding vascular health …

Aims: Recent studies have raised concerns regarding increased heart failure in patients on
dipeptidyl peptidase-4 inhibitors. We examined whether dipeptidyl peptidase-4 inhibitors …

Background Endothelial dysfunction (ED) is a hallmark in type 2 diabetes mellitus (T2DM)
that favor both atherogenesis and ischemia and reperfusion injury (IRI). Sodium-glucose-2 …

Left ventricular (LV) diastolic dysfunction is one of the important mechanisms responsible for
symptoms in patients with heart failure. The aim of the current study was to identify …

Saxagliptin, a potent and selective DPP-4 inhibitor, is characterized by its slow dissociation
from DPP-4 and its long half-life and is expected to have a potent tissue membrane-bound …

Background The cardio-ankle vascular index (CAVI) is a novel physiological marker of
atherosclerosis that reflects systemic arterial stiffness. The aim of this study was to clarify the …