Glycosylation: mechanisms, biological functions and clinical implications

M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Glycosylation in health and disease

C Reily, TJ Stewart, MB Renfrow, J Novak - Nature Reviews Nephrology, 2019 - nature.com
The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …

Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

SS Pinho, I Alves, J Gaifem… - Cellular & Molecular …, 2023 - nature.com
The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

High-throughput glycomic methods

I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …

A unique serum IgG glycosylation signature predicts development of Crohn's disease and is associated with pathogenic antibodies to mannose glycan

J Gaifem, CS Rodrigues, F Petralia, I Alves… - Nature …, 2024 - nature.com
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …

[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases

I Gudelj, G Lauc, M Pezer - Cellular Immunology, 2018 - Elsevier
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …

Plasma markers of disrupted gut permeability in severe COVID-19 patients

LB Giron, H Dweep, X Yin, H Wang, M Damra… - Frontiers in …, 2021 - frontiersin.org
A disruption of the crosstalk between the gut and the lung has been implicated as a driver of
severity during respiratory-related diseases. Lung injury causes systemic inflammation …

Diversity and dynamism of IgA− microbiota interactions

KE Huus, C Petersen, BB Finlay - Nature Reviews Immunology, 2021 - nature.com
IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a
context-dependent manner to both prevent and promote bacterial colonization and to …

[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy

S Shkunnikova, A Mijakovac, L Sironic, M Hanic… - Biotechnology …, 2023 - Elsevier
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …

Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis

J Torres, F Petralia, T Sato, P Wang, SE Telesco… - Gastroenterology, 2020 - Elsevier
Background & Aims Biomarkers are needed to identify patients at risk for development of
inflammatory bowel diseases. We aimed to identify serum biomarkers of Crohn's disease …