Glycosylation: mechanisms, biological functions and clinical implications
M He, X Zhou, X Wang - Signal Transduction and Targeted Therapy, 2024 - nature.com
Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …
during or after translation through the addition or removal of one or more functional groups …
Glycosylation in health and disease
C Reily, TJ Stewart, MB Renfrow, J Novak - Nature Reviews Nephrology, 2019 - nature.com
The glycome describes the complete repertoire of glycoconjugates composed of
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …
carbohydrate chains, or glycans, that are covalently linked to lipid or protein molecules …
Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection
The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …
circuits that regulate host responses against endogenous and exogenous insults. Disruption …
High-throughput glycomic methods
I Trbojević-Akmačić… - Chemical …, 2022 - ACS Publications
Glycomics aims to identify the structure and function of the glycome, the complete set of
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …
oligosaccharides (glycans), produced in a given cell or organism, as well as to identify …
A unique serum IgG glycosylation signature predicts development of Crohn's disease and is associated with pathogenic antibodies to mannose glycan
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …
[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
Plasma markers of disrupted gut permeability in severe COVID-19 patients
A disruption of the crosstalk between the gut and the lung has been implicated as a driver of
severity during respiratory-related diseases. Lung injury causes systemic inflammation …
severity during respiratory-related diseases. Lung injury causes systemic inflammation …
Diversity and dynamism of IgA− microbiota interactions
IgA mediates microbial homeostasis at the intestinal mucosa. Within the gut, IgA acts in a
context-dependent manner to both prevent and promote bacterial colonization and to …
context-dependent manner to both prevent and promote bacterial colonization and to …
[HTML][HTML] IgG glycans in health and disease: Prediction, intervention, prognosis, and therapy
Immunoglobulin (IgG) glycosylation is a complex enzymatically controlled process, essential
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
for the structure and function of IgG. IgG glycome is relatively stable in the state of …
Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis
Background & Aims Biomarkers are needed to identify patients at risk for development of
inflammatory bowel diseases. We aimed to identify serum biomarkers of Crohn's disease …
inflammatory bowel diseases. We aimed to identify serum biomarkers of Crohn's disease …