Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

The induced pluripotent stem cell (iPSC) technology has transformed in vitro research and
holds great promise to advance regenerative medicine. iPSCs have the capacity for an …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …

Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19)
pathogenesis and may predispose to the neurological sequelae associated with long …

Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

The arachnoid barrier delineates the border between the central nervous system and dura
mater. Although the arachnoid barrier creates a partition, communication between the …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Crosstalk between gut and brain has long been appreciated in health and disease, and the
gut microbiota is a key player in communication between these two distant organs. Yet, the …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …