Soluble α-synuclein aggregates varying in size, structure, and morphology have been
closely linked to neuronal death in Parkinson's disease. However, the heterogeneity of …

Alterations in the dopamine catabolic pathway are known to contribute to the degeneration
of nigrostriatal neurons in Parkinson's disease (PD). The progressive cellular buildup of the …

Oxidative decomposition of several biomolecules produces reactive aldehydes. Monoamine
neurotransmitters are enzymatically converted to aldehydes via monoamine oxidase …

The abnormal aggregation of the α-synuclein (αsyn) protein is involved in the formation of
Lewy bodies in the brain of patients suffering from Parkinson disease (PD). Hydroxytyrosol …

Identifying the mechanisms by which the presynaptic protein α-synuclein (aSyn) is
associated with neurodegeneration of dopamine neurons is a major priority in the …

Vestigial dopaminergic cells in PD have selectivity for a sub-class of hypersensitive neurons
with the nigrostriatal dopamine (DA) tract. DA is modulated in pre-synaptic nerve terminals to …

The formation of neurotoxic oligomers of the presynaptic protein α-Synuclein (aSyn) is
suggested to be associated with Parkinson's disease neurodegeneration. In this respect, it …

Dopaminergic neurons are constantly threatened by the thin boundaries between functional
α-synuclein (AS) structural disorder and pathogenic aggregation, and between dopamine …

Oligomeric forms of α‐synuclein are believed to cause mitochondrial injury, which may
contribute to neurotoxicity in Parkinson's disease (PD). Here oligomers of α‐synuclein were …

Purpose Alpha‐synuclein (α‐syn) dopaminylation can lead to the death of dopaminergic
neurons in the brain and is a risk factor of Parkinson's disease (PD). This study aims to …