Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …

Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …

Tumor cells exist in close proximity with non-malignant cells. Extensive and multilayered
crosstalk between tumor cells and stromal cells tailors the tumor microenvironment (TME) to …

Currently, metastasis remains the primary cause of death of patients with breast cancer
despite the important advances in the treatment of this disease. In the complex tumour …

Breast cancer has been shown to live in the tumor microenvironment, which consists of not
only breast cancer cells themselves but also a significant amount of pathophysiologically …

Extensive studies have shown that cells can sense and modulate the biomechanical
properties of the ECM within their resident microenvironment. Thus, targeting the …

The ability to maintain and differentiate cells in vitro is critical to many advances in the field
of bioengineering. However, on traditional, stiff (E≈ GPa) culture substrates, cells are …