Astrocytes: integrators of arousal state and sensory context
The integration of external information with the internal state of the body is central to the
survival of virtually every multicellular organism. However, a complete picture of the …
survival of virtually every multicellular organism. However, a complete picture of the …
Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy
Noradrenaline (NA) release from the locus coeruleus (LC) changes activity and connectivity
in neuronal networks across the brain, modulating multiple behavioral states. NA release is …
in neuronal networks across the brain, modulating multiple behavioral states. NA release is …
Nonlinear slow-timescale mechanisms in synaptic plasticity
C O'Donnell - Current opinion in neurobiology, 2023 - Elsevier
Learning and memory rely on synapses changing their strengths in response to neural
activity. However, there is a substantial gap between the timescales of neural electrical …
activity. However, there is a substantial gap between the timescales of neural electrical …
Distinct catecholaminergic pathways projecting to hippocampal CA1 transmit contrasting signals during navigation in familiar and novel environments
C Heer, M Sheffield - Elife, 2024 - elifesciences.org
Neuromodulatory inputs to the hippocampus play pivotal roles in modulating synaptic
plasticity, sha** neuronal activity, and influencing learning and memory. Recently, it has …
plasticity, sha** neuronal activity, and influencing learning and memory. Recently, it has …
A spatial threshold for astrocyte calcium surge
Astrocytes are active cells involved in brain function through the bidirectional communication
with neurons, in which astrocyte calcium plays a crucial role. Synaptically evoked calcium …
with neurons, in which astrocyte calcium plays a crucial role. Synaptically evoked calcium …
[HTML][HTML] Aberrant hippocampal Ca2+ micro-waves following synapsin-dependent adenoviral expression of Ca2+ indicators
N Masala, M Mittag, EA Giovannetti, DA O'Neil… - eLife, 2024 - elifesciences.org
Genetically encoded calcium indicators (GECIs) such as GCaMP are an invaluable tool in
neuroscience to monitor neuronal activity using optical imaging. The viral transduction of …
neuroscience to monitor neuronal activity using optical imaging. The viral transduction of …
Network-level encoding of local neurotransmitters in cortical astrocytes
Astrocytes, the most abundant non-neuronal cell type in the mammalian brain, are crucial
circuit components that respond to and modulate neuronal activity through calcium (Ca2+) …
circuit components that respond to and modulate neuronal activity through calcium (Ca2+) …
[HTML][HTML] Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain
The brain uses a specialized system to transport cerebrospinal fluid (CSF), consisting of
interconnected ventricles lined by motile ciliated ependymal cells. These cells act jointly with …
interconnected ventricles lined by motile ciliated ependymal cells. These cells act jointly with …
The effects of locus coeruleus ablation on mouse brain volume and microstructure evaluated by high-field MRI
The locus coeruleus (LC) produces most of the brain's noradrenaline (NA). Among its many
roles, NA is often said to be neuroprotective and important for brain upkeep. For this reason …
roles, NA is often said to be neuroprotective and important for brain upkeep. For this reason …
Chemogenetic Control of Striatal Astrocytes Improves Parkinsonian Motor Deficits in Mice
WR Evans, SS Baskar, A Vellore, ARCE Costa… - Glia, 2025 - Wiley Online Library
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic nigrostriatal
inputs, which causes striatal network dysfunction and leads to pronounced motor deficits …
inputs, which causes striatal network dysfunction and leads to pronounced motor deficits …