[HTML][HTML] Diabetes mellitus and Parkinson's disease: shared pathophysiological links and possible therapeutic implications

A Hassan, RS Kandel, R Mishra, J Gautam, A Alaref… - Cureus, 2020 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is the most common chronic metabolic disease. Parkinson's disease
(PD) is considered one of the most common neurodegenerative diseases. There are many …

[HTML][HTML] Ferroptosis—A Shared Mechanism for Parkinson's Disease and Type 2 Diabetes

C Duță, C Muscurel, CB Dogaru, I Stoian - International Journal of …, 2024 - mdpi.com
Type 2 diabetes (T2D) and Parkinson's disease (PD) are the two most frequent age-related
chronic diseases. There are many similarities between the two diseases: both are chronic …

Diabetes causes dysfunctional dopamine neurotransmission favoring nigrostriatal degeneration in mice

I Pérez‐Taboada, S Alberquilla, ED Martín… - Movement …, 2020 - Wiley Online Library
Background Numerous studies indicate an association between neurodegenerative and
metabolic diseases. Although still a matter of debate, growing evidence from …

Effect of diabetes control status on the progression of Parkinson's disease: a prospective study

R Ou, Q Wei, Y Hou, L Zhang, K Liu… - Annals of clinical …, 2021 - Wiley Online Library
Objective To evaluate whether the control status of type 2 diabetes mellitus (DM) influences
the progression of Parkinson's disease (PD). Methods We conducted a prospective cohort …

MicroRNAs, Parkinson's disease, and diabetes mellitus

H Wang - International Journal of Molecular Sciences, 2021 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative disorder that affects 1% of the population
over the age of 60. Diabetes Mellitus (DM) is a metabolic disorder that affects approximately …

Nanocarriers to mediate the pathways from diabetes toward Parkinson's disease

S De, YC Kuo - Journal of the Taiwan Institute of Chemical Engineers, 2024 - Elsevier
Background The connection between type 2 diabetes mellitus (T2DM) and Parkinson's
disease (PD) was first pointed out in the early 1960s. This probable link is still under serious …

Unraveling the Ties: Type 2 Diabetes and Parkinson's Disease-A Nano-Based Targeted Drug Delivery Approach

S De, S Banerjee, P Rakshit, S Banerjee… - Current Diabetes …, 2025 - benthamdirect.com
The link between Type 2 Diabetes (T2DM) and Parkinson's Disease (PD) dates back to the
early 1960s, and ongoing research is exploring this association. PD is linked to …

[HTML][HTML] Insulin and TLR4 Inhibitor Improve Motor Impairments in a Rat Model of Parkinson's Disease

F Hemmati, N Valian, A Ahmadiani… - Iranian Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Background Insulin resistance is an important pathological hallmark of Parkinson's disease
(PD). Proinflammatory cytokines during neuroinflammation decrease insulin sensitivity by …

Evaluation of the relationship between SORL1 gene polymorphism and Parkinson's disease in the Chinese population

Y Wang, M Luan, L Xue, J **, A **e - Neuroscience Letters, 2022 - Elsevier
Objective There is increasing evidence that lysosomal pathway dysfunction is closely linked
to the pathogenesis of Parkinson's disease (PD). Considering the relationship between …

[HTML][HTML] Insulin and TLR4 Antagonist Improve Motor Impairments in a Rat Model of Parkinson's Disease

F Hemmati, N Valian, A Ahmadiani, Z Mohamed… - IJ Pharmaceutical … - brieflands.com
Background: Insulin resistance is an important pathological hallmark of Parkinson's disease
(PD). Proinflammatory cytokines during neuroinflammation decrease insulin sensitivity by …