[HTML][HTML] TGF-β signaling in health and disease
J Massagué, D Sheppard - Cell, 2023 - cell.com
The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity.
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury …
TGF-β Signaling
K Tzavlaki, A Moustakas - Biomolecules, 2020 - mdpi.com
Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …
Specificity, versatility, and control of TGF-β family signaling
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
Contextual determinants of TGFβ action in development, immunity and cancer
Few cell signals match the impact of the transforming growth factor-β (TGFβ) family in
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
metazoan biology. TGFβ cytokines regulate cell fate decisions during development, tissue …
BMP signalling in skeletal development, disease and repair
VS Salazar, LW Gamer, V Rosen - Nature Reviews Endocrinology, 2016 - nature.com
Since the identification in 1988 of bone morphogenetic protein 2 (BMP2) as a potent inducer
of bone and cartilage formation, BMP superfamily signalling has become one of the most …
of bone and cartilage formation, BMP superfamily signalling has become one of the most …
TGF-β family signaling in tumor suppression and cancer progression
J Seoane, RR Gomis - Cold Spring Harbor perspectives …, 2017 - cshperspectives.cshlp.org
Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …
TGFβ signalling in context
J Massagué - Nature reviews Molecular cell biology, 2012 - nature.com
The basic elements of the transforming growth factor-β (TGFβ) pathway were revealed more
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
than a decade ago. Since then, the concept of how the TGFβ signal travels from the …
Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis
Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …
tissue following injury involves dynamic interactions between multiple cell types, growth …
Transcriptional control by the SMADs
CS Hill - Cold Spring Harbor perspectives in biology, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) family of ligands elicit their biological effects by
initiating new programs of gene expression. The best understood signal transducers for …
initiating new programs of gene expression. The best understood signal transducers for …
Structural determinants of Smad function in TGF-β signaling
Smad transcription factors are central to the signal transduction pathway that mediates the
numerous effects of the transforming growth factor β (TGF-β) superfamily of cytokines in …
numerous effects of the transforming growth factor β (TGF-β) superfamily of cytokines in …